Thursday, March 1, 2012

Heart disease and stroke mortality are highest in countries with low saturated fat consumption

Background: In 1993, Artaud-Wild et al published an article linking per capita intakes of saturated fat to mortality rates from coronary heart disease (CHD) (1). A global analysis was done including data from 40 countries. Figure 1 shows that a strong positive correlation (R = 0.78) was found between a "cholesterol-saturated fat index" and CHD mortality among men. This correlation was similar for the % of energy from saturated fat intake (R = 0.77).

Figure 1:

Is more recent data available?
No articles about this correlation were published since. But in 2008, the British Heart Foundation published the European Cardiovascular Disease Statistics (2). The report included European mortality rates from both CHD and stroke for 1972 to 2005 for both men and women. In addition, it provided data about European per capita consumption of saturated fat for the year 1998. This data gives us the possibility to link saturated fat intake to mortality rates in 1998. A total of 41 countries had available data about both saturated fat intake and mortality rates for this year. I used a simple Pearson correlation to examine if a significant correlation could be found. The effect can be seen in figure 2.

Figure 2:

Results: unexpectedly, the highest mortality rates from CHD were found in the countries with the lowest intakes of saturated fats. The correlation was significant (2-tailed significant at < 0.01). The R2 for linearity = 0.34.

How can this difference in effect be explained?
  • Artaud-Wild et al used data from the year 1977, I used data from 1998.
  • Artaud-Wild et al used mortality rates that were not adjusted for age. I used age-standardized mortality rates.
  • Artaud-Wild et al used a global analysis including 40 countries. I used a European analysis including 41 countries. Sadly, I could not find data about more countries.
Were results similar looking at women or at stroke mortality?
Pearson correlations showed that higher mortality rates were consistently linked to lower intakes of saturated fat (two-tailed significance = < 0.01 for all). In addition to the correlation shown in figure 2, I also examined 3 other end points. Correlations were slightly stronger than the one seen in figure 2. Results are as follows:
  • Male stroke mortality: R2 = 0.38
  • Female CHD mortality: R2 = 0.43
  • Female stroke mortality: R2 = 0.43
Conclusion: a global analysis including 40 countries showed that higher intakes of saturated fat were linked to higher mortality rates from coronary heart disease among men in 1977. But a European analysis including 41 countries showed that lower intakes of saturated fat were linked to higher mortality rates from both coronary heart disease and stroke in both genders in 1998...............................

1) Artaud-Wild SM et al. Differences in coronary mortality can be explained by differences in cholesterol and saturated fat intakes in 40 countries but not in France and Finland. A paradox. Circulation. 1993 Dec;88(6):2771-9.
2) Allender S et al. European cardiovascular disease statistics 2008 edition.  


3 reacties:

Arthritis Treatment said...

Thanks for the information... I really love your blog posts... specially those onTreatment For Heart Failure India

Anil Kumar said...

The best thing that you can to sooner than you begin treatment for your child is to top cancer hospitals in India to make sure that you are receiving them to a trustworthy hospital that is up to date on the latest in cancer treatments and research as you want to offer them the best possible opening of getting well again.

Miyushi Izumisa said...

Good sharing, I would recommend Vida Cardio-ceautical Drink for those who are suffering from heart disease or any type of cardio-vascular diseases. It is prepared by adding the powdered juice to 500ml of water. It can be drink just like any ordinary juice but has a very good effect to heart. Vida has undergone 10 years of development and testing and with self-affirmed Generally Recognized as Safe (GRAS) status by an independent panel of experts, and is produced according to Food GMP (Good Manufacturing Principles). Read more at:

Post a Comment

Twitter Delicious Facebook Digg Stumbleupon Favorites More

Design by Free WordPress Themes | Bloggerized by Lasantha - Premium Blogger Themes | Facebook Themes